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KMID : 0613820110210091310
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Journal of Life Science
2011 Volume.21 No. 9 p.1310 ~ p.1314
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Septicine Inhibits the Production of Inflammatory Mediators in Lipopolysaccharide-Stimulated Murine Macrophages
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Park Geun-Mook
Kim Jin-Kyung
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Abstract
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Anti-inflammatory activities of septicine, a natural alkaloid product present in the leaves and stems of Tylophora ovata, were evaluated in lipopolysaccharide (LPS)-stimulated murine macrophages, RAW264.7 cells. Treatment with septicine inhibited LPS-induced nitric oxide (NO), inflammatory cytokines, tumor necrosis factor-α and interleukin-6 production in a concentration-dependant manner. In addition, septicine suppressed the expression of inducible NO synthase. These results suggest that the anti-inflammatory activities of septicine might be attributed to the inhibition of NO, iNOS and cytokine expression.
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KEYWORD
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Inflammation, lipopolysaccharide, macrophages, septicine
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